Research Library

The international Human Microbiome Project trumpeted the coming of age of the field of metagenomics, the study of entire communities of microbes and their contributions to health and disease. In parallel, the field of metabolomics emerged as the systematic, nonbiased analysis of all low-molecular-weight small molecules, or metabolites, produced by a system in response to an environmental stimulus. These fields have enabled discoveries pertinent to a number of human conditions — namely, acute gastroenteritis, antibiotic-associated diarrhea, inflammatory bowel disease, irritable bowel syndrome, liver disease, undernutrition and obesity — and have begun to shed new light on multiple aspects of the neglected tropical diseases.

The success of Yemen's efforts to control neglected tropical diseases provides important lessons for conducting disease control activities in the face of civil unrest, extreme instability and poverty, writes Peter Hotez, fellow in disease and poverty, in PLOS Neglected Tropical Diseases.

Peter Hotez discusses his work on neglected tropical diseases and the future direction of disease elimination and science diplomacy. Published in the journal Molecular Medicine, December 2014.

Today, neglected tropical diseases represent some of the most common afflictions of global Christianity. Through NTDs, a renewed dialogue with faith-based organizations that work in developing countries and elements of the hierarchy of the Christian church could make an important difference in global Christianity and the lives of the world's poorest people.

A new analysis reveals substantial global health gains for AIDS, malaria and neglected tropical diseases that were first targeted by the administration of President George W. Bush in 2003 and then greatly expanded by the Obama administration. Beginning in 2016, an incoming administration will have opportunities to build on this legacy to control and eliminate poverty-related diseases — including those with pandemic potential — and to assert American leadership while being mindful of fiscal constraints.

This review highlights new information on the major neglected parasitic infections affecting impoverished Americans, with respect to their distribution and unique clinical presentations as well as their surprising links to cardiovascular, respiratory and neuropsychiatric conditions ordinarily thought of as noncommunicable diseases.

This study is a systematic review to assess the prevalence of toxocariasis in North America and whether selected groups are at risk for infection. Further research is needed to determine the true current burden of toxocariasis in North America; however, the prevalence estimates gathered in this review suggest that the burden of disease is significant.

This article analyzes the "Global Burden of Disease Study 2010" and examines the study's implications for neglected tropical diseases.

Peter Hotez, fellow in disease and poverty, proposes ways for countries around the world to increase their reliance on vaccine diplomacy in their foreign policy approaches.

In this article, Peter Hotez, fellow in disease and poverty, summarizes 10 of the worst global “hotspots” where neglected tropical diseases predominate.